Citation: Durali D, de Goër de Herve M-G, Gasnault J and Taoufik Y (2015) B cells and progressive multifocal leukoencephalopathy: search for the missing link. Front. Immunol. 6:241. doi: 10.3389/fimmu.2015.00241
*Correspondence: Deniz Durali, Department of Medical Microbiology, School of Medicine, Istanbul Medipol University, Kavacik Mh. Ekinciler Cd. No. 19, Beykoz 34810, Istanbul, Turkey, firstname.lastname@example.org; Yassine Taoufik, IMVA-INSERM U1184, Faculté de Médecine, 63 rue Gabriel Péri, 94276 Le Kremlin-Bicêtre Cedex, France, email@example.com
A full report was released by the Athletics Integrity Unit on Tuesday that announced a disciplinary tribunal panel upheld Coleman\u2019s two-year suspension for missing three drug tests in a 12-month span. The ban was backdated to start May 14 and will expire on May 13, 2022, which knocks him out of the Summer Games in Tokyo.
\u201CWith fewer than six months until Patriots\u2019 Day and with road races prohibited until Phase 4 of the Massachusetts reopening plan, we are unable to host the Boston Marathon this coming April,\u201D BAA CEO Tom Grilk said in a statement. \u201CBy shifting our focus to a fall date, we can continue to work with stakeholders to adjust the in-person experience for runners and supporters alike. Prioritizing the safety of participants, volunteers, spectators, and community members, we continue to assess all elements of the race including a potential reduced field size or weekend date.\u201D
Leeper was fifth at the U.S. Outdoor Championships last year in 44.38, which would have put him in the running to participate in the relay pool for the world championships. However, World Athletics didn\u2019t allow him and noted \u201Crules permit competitive use of aids such as prosthetics if they do not give the user an artificial competitive advantage over those not using such aids\u201Dbut Leeper\u2019s did.
Major props once again to Keith and Kevin Hanson for organizing last week\u2019s ekiden and this week's half marathon. (For more on them and how they\u2019ve done their part to advance American distance running, feel free to revisit my live podcast with them from February. I miss doing live shows.)
Brian is a super nice guy who I met in Boulder a few months ago. He\u2019s a member of the Tinman Track Club and he\u2019s run 2:30:14 for the marathon. He ran his first marathon in 3:18 just four years ago. His background doesn\u2019t have much running. He was a snowboarder growing up and then really partied in college. He decided to make a change in his life when he stepped on the scale and wasn\u2019t happy with where he was at. It led him to boxing, which then led him to running following an injury. It\u2019s all interesting to me and I think you\u2019ll enjoy it as well.
In early June 2013, while in preparation in Barcelona for the 2013 World Championships in Athletics, he contracted liver disease (hepatitis A) and was hospitalized on June 12. He only ran the Mile race in Eugene, Oregon on June 1, 2013  and later announced not participating at the world championships in Moscow that year.
Makhloufi missed the entire 2017 and 2018 seasons due to injury and couldn't take part of the 2017 World Athletics Championships in London. He finished second behind Kenyan Timothy Cheruiyot in the 1500 m at the 2019 World Championships in Athletics in Doha winning his first medal at a world championship with a season best time of 3:31.38.
The part, known as a flaperon, was found on the shore of the French-governed island on July 29 and Malaysian authorities have said paint colour and maintenance-record matches proved it came from the missing Boeing 777 aircraft.
In the end, there was a shock silver medallist as US champion Leo Manzano, who was just 10th at the bell and 8th with 200 meters remaining and 6th with 100 remaining, used a fantastic kick in the last 200 and particularly in the last 100 to mow down the field and finish second in 3:34.79, earning America it's first Olympic silver since Jim Ryun won silver 44 years ago in 1968. Last year's bronze medallist Matt Centrowitz, who was just ahead of Manzano for most of the last 200, closed well also and ended up just missing a medal as his lean at the line came up just a bit short of Morocco's Abdalaati Iguider, who ran 3:35.13 to Centrowitz's 3:35.17.
Nonepileptic seizures are involuntary episodes of movement, sensation, or behaviors (e.g., vocalizations, crying, other expressions of emotion) that do not result from abnormal cortical discharges. The seizures can mimic any kind of epileptic seizure and thus can be mistaken for generalized tonicclonic seizure, absence seizure, and simple or complex partial seizures.1 Early recognition and appropriate treatment of nonepileptic seizures can prevent significant iatrogenic harm and may result in a better outcome.
The presence or absence of self-injury and incontinence, the ability to induce seizures by suggestion, psychologic tests, historical factors, and ambulatory electroencephalography (EEG) have been found to be insufficient for the diagnosis of psychogenic nonepileptic seizures.1,6 Postictal prolactin levels greater than two times the upper limit of normal once were thought to differentiate generalized and complex partial seizures from psychogenic nonepileptic seizures but recently have been shown to be unreliable.7
Early diagnosis of psychogenic nonepileptic seizures is important economically. One study12 demonstrated an 84 percent reduction in total seizure-related medical charges in the six months after diagnosis of psychogenic nonepileptic seizures: average diagnostic test charges decreased by 76 percent, medication charges decreased by 69 percent, outpatient visits decreased by 80 percent, and emergency department visits decreased by 97 percent.
From 43 to 100 percent (median: 73.5 percent) of patients with psychogenic nonepileptic seizures have concurrent psychiatric disorders28 (Table 3).25 The disorders tend to be related to trauma, and include posttraumatic stress disorder (PTSD) and other anxiety disorders; depressive disorders; and conversion, somatization, and dissociation disorders. Personality pathology, particularly of the borderline type, is common.29 Frequently, patients with psychogenic non-epileptic seizures also have other dissociative and somatization symptoms.18,30
French rider Mickael Bourgain quit the cycling road race after just a few kilometres as planned on the first weekend of the Games having been forced to take part in order to compete in his favoured keirin track event.
Overall, risk management involves looking at several conditions and tactics, with different criteria. These must be agreed upon between the PTAs/PTOs, payment schemes, and acquiring and issuing banks as part of the liability framework. This process is complex and time-consuming. Moreover, travelers can use the service relatively anonymously, meaning PTAs/PTOs risk losing part of their customer base, along with deploying more complex software to integrate concessions.
Providing a frictionless experience to users across modes is associated to the successful integration between technical ticketing systems. Fare media digitization and user interaction are just part of this complex transformation, but the perfect communication between different back ends enables outstanding CX. We identify two main integration models that eventually will have an impact on how MaaS will be deployed:
Beyond mobility services and technical integration for MaaS, a unified ticketing and payment scheme setup is paramount for greater interoperability. Whatever the integration model, there is a need for participants in a transport scheme to collaborate at all levels, from public authority to service providers, public organizations to private companies. Beyond technical issues, success is met when silos are broken; governance policy is clear; and management of entitlement, payment, and revenue collection are correctly integrated. Regarding funding, financial and tax rules must be well understood and accepted, with liabilities for service delivery as a whole or integrated journeys agreed upon, along with a push for an open, formalized ecosystem to easily onboard new service providers. Only then does a seamless CX, with integrated fare media across modes, public and private, become feasible. 781b155fdc